Furthermore, the marked decrease in AMH levels observed in the CARB group was significantly reversed by melatonin and glutathione, indicating preservation of the ovarian reserve
In addition, local hypoxic, acidic, and low-glucose environments further augment energy metabolism reprogramming in tumor cells, which not only upregulates antiapoptotic proteins, including protein kinase B (Akt) and hexokinase 2 (HK2) but also inhibits the proliferation of T lymphocytes, facilitating tumor cell immune escape [198]
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